Setting The Context -- Should We Be Worried? -- Using Nature to Build A Weapon -- Science, Society and Safety -- What Can We Learn From the Past? -- Scientists, Culture, and Ideology -- From the Lab to the Battlefield-and Beyond -- Select Agents: Yesterday and Today -- Keeping Track of Risky Pathogens -- Most Common: Anthrax -- The Most Feared: Smallpox -- Threats From Other Select Agents -- Bioterrorism Comes to the U.S. -- Anthrax Spores in the US Postal System -- What We have -- and What We Need -- New Policies Reflect Changing Risk Assessment -- From Policy to Implementation: The Biological Emergency Response System -- How Are We Doing? Dimensions of this Wicked Problem -- Solving the Puzzle: A Comprehensive Biosecurity System.