Targeted therapeutic injections of joints, periarticular structures, tendon sheaths or bursae are among the most important treatments for inflammatory rheumatic or inflammatory activated degenerative diseases of the musculoskeletal system. Furthermore, injections of periarticular structures are also performed in post-traumatic situations or in overuse syndromes. In this publication, we discuss indications, contraindications, the clinical and ultrasound-guided techniques preferred by the authors, and possible adverse drug reactions and side effects of intraarticular and periarticular injection.