The introduction and diffusion of PICCs in Italy has been historical- ly linked to the GAVeCeLT association (the Italian Group of Long Term Venous Access Devices) and particularly to the authors' scientific and didactic activity. This volume examines the clinical indications for these devices and illustrates the details of their insertion and management in several clinical settings. Furthermore, all the specifications regard- ing the materials to use and all the aspects related to device removal and replacement, as well as the different strategies for complications prevention, are thoroughly discussed.