This compact volume is focused on an eclectic mix of biotechnological and biomedical applications of stimuli-sensitive polymeric materials. It starts with their chemical synthesis and design strategies. This is followed by discussions of their applications in microfluidics, biosensors, wound healing and anticancer therapy.Two other interesting applications covered are the design of aptamer-based smart surfaces for biological applications and use of smart hydrogels in tissue engineering.In general, it provides a snapshot of the current state-of-the-art in design and applications of smart systems at the interfaces of biological sciences.