The International Conference Zaragoza-Pau on Mathematics and itsApplications was organized by the Departamento de Matem.tica Aplicada, the Departamento de M.todos Estad.sticos and the Departamento deMatem.ticas, all of them from the Universidad de Zaragoza (Spain), and the Laboratoire de Math.matiques et de leurs Applications, from theUniversit. de Pau et des Pays de l'Adour (France). This conference has been held every two years since 1989. The aim of this conference isto present recent advances in Applied Mathematics, Statistics and Pure Mathematics, putting special emphasis on subjects linked to petroleum engineering and environmental problems.TheSixteenth Conference took place in Jaca (Spain) from 7th to 9thSeptember 2022. The official opening ceremony was graced by thepresence of the Vice?Chancellor for Academic Policy of the Universityof Zaragoza, D. Jos. .ngel Castellanos G.mez, and Vice?Chancellor ofthe Research Commission of the University of Pau, Mme. IsabelleBaraille. During those three days, 111 mathematicians, coming fromdifferent universities, research institutes or the industrial sector,attended 8 plenary lectures, 69 contributed talks and a poster session with 7 posters. We note that in this edition there were 11mini-symposia, five of them co-organized by colleagues from theUniversidad de Zaragoza and the Universit. de Pau et des Pays del'Adour.