Across Europe, regional development agencies (RDAs) have become a central feature of regional policy, both as innovative policy-makers and as the implementers of programmes and initiatives originating from the national or European level. Since the first generation of RDAs were established in the 1970s and 1980s, major changes have swept through the policy arena: - globalisation has increased competitive pressure and moved the position of regions in the international division of labour to the forefront of regional strategy-making - the digital revolution and the EU Lisbon agenda have highlighted the importance of production and access to knowledge as key factors in regional competitiveness - regional policy has become part of a wider system of multi-level governance so that their geographical horizon has expanded in terms of sponsors and collaborators - issues of governance and accountability of RDAs have been one of the drivers to devolution of powers to governments and bodies below the level of the nation state, raising questions over their status and distance from political control. The aim of this book is to develop a profile of the next generation of RDAs that will identify key issues and trends regarding: policy aims, strategy-making and the new role of knowledge; the organisation of policy delivery, with emphasis on interactive knowledge brokerage; the organisational shift towards smaller and more flexible RDAs; and the political governance of regional policy. By drawing on a combination of conceptual reflection, surveys, comparative research, and systematic use of critical case studies, the book provides a new point of reference by identifying key features of the current, and, indeed next, generation of regionally-based economic development organisations.