On September 27 ? October 3, 2008 the NATO Advanced Research Workshop (ARW) on progress in high-energy physics and nuclear safety was held in Yalta, Crimea (see: http://crimea.bitp.kiev.ua and http://arw.bitp.kiev.ua). Nearly 50 leading experts in high-energy and nuclear physics from Eastern and Western Europe as well as from North America participated at the Workshop. The topics of the ARW covered recent results of theoretical and experimental studies in high-energy physics, accelerator, detection and nuclear technologies, as well as problems of nuclear safety in high-energy experimentation and in nuclear - dustry. The forthcoming experiments at the Large Hadron Collider (LHC) at CERN and cosmic-ray experiments were among the topics of the ARW. An important aspect of the Workshop was the scienti?c collaboration between nuclear physicists from East and West, especially in the ?eld of nuclear safety. The present book contains a selection of invited talks presented at the ARW. The papers are grouped in two parts.