This book focuses on a relatively new approach to chemical analysis in general and to separation science in particular. It covers the combination of thin-layer chromatography (TLC) and high performance TLC (HPTLC), one of the most simple, cost-effective, and well-performing techniques for determining complex mixtures of compounds along with mass spectrometry (MS), a sophisticated and relatively expensive spectrometric technique that enables rapid identification of separated chemical species. In addition to that, the book covers electrophoretic ? MS methods and applications.