The Newport Serial Killer relates the tale of a grisly series of murders which take place in Newport, Rhode Island. There are no clues as Police Lieutenant Clayhill and his partner, Sergeant Souza, struggle to discover and apprehend the brutal murderer of three young women, each murder taking place on a national holiday. Many leads and many interrogations lead nowhere until finally a confession is received. The confessed killer, Lloyd Krubick, is quickly tried, convicted and sentenced to a life term in prison, where in a short time he is killed by other prisoners.

While all is now calm in Newport, murders start happening in Miami, Florida, which are hauntingly similar to those in Newport. Could this be a copycat killer? Or was Krubick's confession false and has the real Newport killer moved south? Clayhill and Souza go to Miami to solve the mystery.