This textbook covers the entire subject of the regulation of cerebral blood flow, with special emphasis on neurogenic mechanisms, and relationships with physiological and pathophysiological mechanisms. Both research and clinical aspects are covered. Established authorities in the field of cerebral circulation and metabolism, backed up by other internationally known neuroscientists, have prepared this in-depth text-book review of cerebral circulation and its control, together with the necessary background information in neuroanatomy, neurophysiology, neurochemistry, pharmacology and vascular physiology. Techniques of investigation of cerebral circulation and metabolism are dealt with in a comprehensive manner, allowing the reader to evaluate approaches to a particular research problem and to assess the reliability of published results. Particular emphasis is given to the role and effects of neurotransmitters and neural systems -- extrinsic and intrinsic -- in controlling cerebral blood flow, while two chapters deal with related clinical disorders. A carefully selected reference list allows further personal research by the interested reader. Eminently readable (number of text references limited), well illustrated, seriously documented and up-to-date. This is a suitable reference book for graduate level onwards, and should be of special interest to all those in or entering this field of research. It should be of interest to researchers in physiology, pharmacology, and anatomy, neuroscience, as well as clinicians, especially neurologists, neurosurgeons and nuclear medicine specialists of the brain.