This book presents refereed proceedings of the Second International Conference Neural Computing for Advanced Applications, NCAA 2021, held in Guangzhou, China, in August, 2021. The 54 full papers papers were thorougly reviewed and selected from a total of 144 qualified submissions. The papers are organized in topical sections on neural network theory, cognitive sciences, neuro-system hardware implementations, and NN-based engineering applications; machine learning, data mining, data security and privacy protection, and data-driven applications; neural computing-based fault diagnosis, fault forecasting, prognostic management, and system modeling; computational intelligence, nature-inspired optimizers, and their engineering applications; fuzzy logic, neuro-fuzzy systems, decision making, and their applications in management sciences; control systems, network synchronization, system integration, and industrial artificial intelligence; computer vision, image processing, and their industrial applications; cloud/edge/fog computing, the Internet of Things/Vehicles(IoT/IoV), and their system optimization; spreading dynamics, forecasting, and other intelligent techniques against coronavirus disease (COVID-19).