Cover -- Title Page -- Copyright Page -- Contents -- Introduction. Iron, Aging, and Human Disease: Historical Background and New Hypotheses -- PART I: CHEMISTRY AND MOLECULAR BIOLOGY OF IRON AND IRON-BINDING PROTEINS -- 1. Structure and Molecular Biology of Iron-Binding Proteins and the Regulation of Free Iron Pools -- 2. Genetic Regulation of the Iron Transport and Storage Genes: Links with the Acute Phase Response -- PART II: IRON ACCUMULATION AND METABOLISM IN HUMANS -- 3. Iron Balance in Western Societies as Measured by Serum Ferritin -- 4. Hereditary Hemochromatosis and Other Diseases Associated with Iron Overload -- 5. Iron and the Immune System -- 6. Cellular Acquisition of Iron and the Iron-Withholding Defense Against Microbial and Neoplastic Invasion -- PART III: IRON AND OXIDATIVE STRESS -- 7. Iron and Damage to Biomolecules -- 8. Lipofuscin, Lysosomes, and Iron -- PART IV: ROLES FOR IRON IN CARDIOVASCULAR DISEASE -- 9. Role of Iron in the Oxidative Modification of Low Density Lipoprotein -- 10. The Role of Iron in Myocardial Reperfusion Injury -- 11. Stored Iron as a Risk Factor for Ischemic Heart Disease -- 12. Iron and Stroke -- PART V: ROLES FOR IRON IN OTHER COMMON DISEASES -- 13. Iron and Cancer -- 14. Brain Iron and Nigrostriatal Dopamine Neurons in Parkinson's Disease -- 15. Proteins of Iron Regulation in Alzheimer's Disease -- 16. Rheumatic Diseases -- 17. Iron and Ethanol-Induced Tissue Damage: Generation of Reactive Oxygen Intermediates and Possible Mechanisms for Their Role in Alcohol Liver Toxicity -- 18. Iron Metabolism and Oxygen Radical Injury in Premature Infants -- PART VI: IMPLICATIONS FOR PREVENTION AND THERAPY -- 19. Preventive Measures for the Maintenance of Low but Adequate Iron Stores -- 20. Therapeutic Strategies to Inhibit Iron-Catalyzed Tissue Damage -- Epiloque. Iron and Oxidative Balance -- INDEX