During the second century the Christian world was shaken by the Gnostics. Irenaeus came from Asia Minor via Rome to become bishop of Lyons, clarify Christian doctrines and fight the Gnostics with a major, five-volume work. He was a living part of his contemporary culture and his approach filled early Christian thought with new life. The writings of Irenaeus exist as a whole only in Latin and Armenian. This study offers new translations of significant parts of his work, critically based on a complete reconstruction of the original Greek in the French series Sources Chretiennes. This collection of sources will also be an invaluable resource for students of the Early Church.