Dune: House Atreides chronicles the early life of Leto Atreides, prince of a minor House in the galactic Imperium. Leto comes to confront the realities of power when House Vernius is betrayed in an imperial plot involving a quest for an artificial substitute to melange, a substance vital to interstellar trade that is found only on the planet Dune. Meanwhile, House Harkonnen schemes to bring Leto into conflict with the Tleilax, and the Bene Gesserit manipulate Baron Harkonnen as part of a plan stretching back 100 generations.