When a parent or parental figure is diagnosed with an illness, the family unit changes and clinical providers should consider using a family-centered approach to care, and not just focus on the patient coping with the illness. Helping Children and Families Cope with Parental Illness describes theoretical frameworks, common parental illnesses and their course, family assessment tools, and evidence-supported family intervention programs that have the potential to significantly reduce negative psychosocial outcomes for families and promote resilience. Most interventions described are culturally sensitive, for use with diverse populations in diverse practice settings, and were developed for two-parent, single-parent, and blended families.