Handbook of Statistics: Step by Step Mathematical Solutions is a pedagogical guide that provides a practical review of the most commonly used statistical models in the social sciences. The mathematical procedures are explained step by step allowing the reader to use or apply them to solve real problems (at scientific and business level), make objective decisions based on evidence, and develop original research related to behavioral and health sciences. Likewise, the design of the contents is completely functional: all are intended to enable the student to understand and apply statistics without previous knowledge of mathematics. In addition, with the aim of promoting the use of free open access software, we explain in an illustrated way how to use JAMOVI, which is specialized in data analysis and uses the R programming language. This manual is designed for students pursuing university degrees associated with communication sciences, behavioral sciences, business and humanities.