As the world has entered the era of big data, there is a need to give a semantic perspective to the data to find unseen patterns, derive meaningful information, and make intelligent decisions. This 2-volume handbook set is a unique, comprehensive, and complete presentation of the current progress and future potential explorations in the field of data science and related topics.Handbook of Data Science with Semantic Technologies provides a roadmap for a new trend and future development of data science with semantic technologies. The first volume serves as an important guide towards applications of data science with semantic technologies for the upcoming generation and thus becomes a unique resource for both academic researchers and industry professionals. The second volume provides a roadmap for the deployment of semantic technologies in the field of data science that enables users to create intelligence through these technologies by exploring the opportunities while eradicating the current and future challenges. The set explores the optimal use of these technologies to provide the maximum benefit to the user under one comprehensive source.This set consisting of two separate volumes can be utilized independently or together as an invaluable resource for students, scholars, researchers, professionals, and practitioners in the field.