Assessment and management of chemical and biohazard risks requires an understanding of the risks in the laboratory, the environment, and the community. This handbook provides guidance on best management practices to help prevent costly oversights and dangers in practice, in industrial and scientific settings. It offers tools to actively avoid ill effects by addressing complacency, promoting good laboratory ethics, and encouraging proactive strategies to minimize risk. This handbook examines the safety culture of chemicals in a laboratory setting, simultaneously serving both as a proactive management exercise and as a means of preventing costly oversights and dangers in practice.