Cover -- Title Page -- Copyright Page -- TABLE OF CONTENTS -- SECTION 1: GENERAL CONCEPTS -- Chapter 1: The Classical Concepts of the Origin and Development of Malignant Tumors -- Chapter 2: Control of Gene Expression during Cell Cycle and Growth of Mammalian Cells -- Chapter 3: Transit, Exit, and Arrest Models for Control of the Mammalian Cell Cycle -- Chapter 4: Cancer-A Disease of Tissue Neogenesis? -- Chapter 5: Neoplasia and the Wound Response: The Lesson Learned from the Multistage Approach of Skin Carcinogenesis -- SECTION 2: CELL TRANSFORMATION -- Chapter 1: The Role of Polypeptide Growth Factors in Phenotypic Transformation of Normal Cells -- Chapter 2: Density-Development Control of Cell Proliferation: Molecular Mechanisms Involved in Contact-Inhibition -- Chapter 3: Cancer as a Mutation-Driven Evolutionary Process -- Chapter 4: Mutation-Driven Evolution of Rev-T -- Chapter 5: Expression of ras, myc, and erb-A Proto-Oncogenes in Preneoplastic Rat Liver during Chemical Carcinogenesis -- Chapter 6: Oncogene Expression in Preneoplastic and Neoplastic Lesions -- Chapter 7: Timing of Proto-Oncogene Replication and its Relationship to Transformation Sensitivity to Chemical Carcinogens -- Chapter 8: The Roles of Cell Proliferation and Gene Replication in Neoplastic Transformation -- Chapter 9: Oncogene Amplification: myc and neu Oncoproteins -- Chapter 10: Structure, Expression, and Oncogenic Activity of the myc Gene Family -- Chapter 11: The myc Family of Nuclear Oncoproteins: Structure, Biochemistry, and Activities -- SECTION 3: FROM FACTOR DEPENDENCE TO FACTOR INDEPENDENCE -- Chapter 1: Critical Variables for the Oncogene-Induced Immortalization of Fischer Rat Embryo Cells -- Chapter 2: Biological Aspects of the Process -- Chapter 3: Immortalization of Cultured Mammalian Cells: A brief Review of the Recent Literature