Detalls del llibre
Why estimands are important -- Estimands and how to define them -- Strategies for dealing with intercurrent events -- Real world examples in choosing and specifying estimands -- Causal inference and estimands -- Putting the principles into practice -- Overview of estimators -- Modeling considerations -- Overview of analyses for composite intercurrent event strategies -- Overview of analyses for hypothetical intercurrent event strategies -- Overview of analyses for principal stratification intercurrent event strategies -- Overview of analyses for while-on-treatment intercurrent event strategies -- Overview of analyses for treatment policy intercurrent event strategies -- Missing data -- Sensitivity analyses -- Example data -- Direct maximum likelihood -- Multiple imputation -- Inverse probability weighted generalized estimated equations -- Doubly robust methods -- Reference-based imputation -- Delta adjustment -- Overview of principal stratification methods -- Analytic case study of depression clinical trials -- Analytic case study #2 -- Analytic case study #3.
Llegir més - Autors Craig H. Mallinckrodt, Geert Molenberghs, Ilya Lipkovich, Bohdana Ratitch
- ISBN13 9781032242620
- ISBN10 1032242620
- Pàgines 344
- Any Edició 2021
- Fecha de publicación 13/12/2021
Ressenyes i valoracions
Estimands, Estimators and Sensitivity Analysis in Clinical Trials
- De
- Craig H. Mallinckrodt, Geert Molenberghs, Ilya Lipkovich, Bohdana Ratitch
- |
- ROUTLEDGE (2021)
- 9781032242620



