Abstract: A state-of-the-art reference text for toxicologists, oncologists, nutritionists, and clinical investigators provides 15 technical reviews of various aspects of drug-nutrient interactions, organized into 2 parts. The first part is devoted to the effects of food and nutrient intake on the disposition of foreign compounds. The second part discusses research activities on the effects of drug on nutrition. Topics include the interpretation of serial or parallel studies of xenobiotics in dietary studies with test animals; the effect of nutrients on chemical carinogeneis; and the interpretation of aberrant effects of therapeutic drugs that may be accounted for by the effects of food on drug deposition or the effects of drug on nutritional status. Numerous data tables are presented throughout and reference citations are appended to each of the review papers. (wz).