This book provides an overview of disease surveillance and frames a roadmap of how newer technologies may allow all countries of the world to reach compliance with the IHR (International Health Regulations established by the World Health Organization) as it pertains to disease detection. It examines examples of existing functional disease surveillance systems and evaluates promising advances and opportunities for new systems. It is an essential reference resource in advanced undergraduate public health courses as well as graduate level courses in any MPH and selected PhD public health curricula.