This guide explains how to apply health economic evaluation techniques to both clinical trial and non-clinical trial data. Through a simple, applied approach using examples and SAS software, the book helps statisticians and researchers in health economics assess cost-effectiveness. It covers trial design, case report form design, quality of life measures, sample sizes, submissions to regulatory authorities for reimbursement, Markov models, cohort models, and decision trees. Examples and case studies are provided at the end of each chapter.