The purpose of the book is to explain the current state of the art use of calcium antagonists in hypertension and, specifically, hypertensive and diabetic kidney disease. The authors offer an up to date insight in the changing world of calcium channel blockers. Furthermore, scientific research has improved drug designs with better pharmacodynamic profile that allows once daily administration and twenty four hours antihypertensive effects. These achievements on effectiveness have been accompanied by reduced effects when compared with classical calcium antagonists. Most interestingly, this book examines new calcium channel blockers, which may effect kidney microcirculation. A comprehensive review of experimental and clinical facts directed to both basic research and clinical practice is also given in this book.