This book focuses on interesting topics in plant Biotechnology applications. The first section, It describes recent progress in genetics transformation techniques using Agrobacterium, It mentions innovative ways to design synthetic seeds. Also, it gives up to date on the phytoremediation aspects and approaches to clean up the environment. The second section is specific on some medicinal plants and their Plant secondary metabolites pharmaceutical uses and applications in curing some diseases as cancer and other diseases as well their potential as drugs against antibiotic resistance bacteria. The third section is dealing with the innovative plant molecular pharming and the usefulness and the possibility to use different plant host systems to produce and design new interesting drugs to treat different illnesses and diseases