This continuing series gathers and presents original research results on the leading edge of medicine and biology. Each article has been carefully selected in an attempt to present substantial topical data across a broad spectrum. Topics discussed include polyclonal antibodies; non-steroidal anti-inflammatory drugs in oral health care; pneumonia risk factors and prevention; polyisoprenylated methylated protein methylesterase and the fulcrum of chemopreventive effects of NSAIDs and PUFAs; mammalian target of rapamycin (mTOR); in-depth review of ANCA-associated vasculitis; use of NSAIDs as part of an adjuvant or palliative therapy in animal cancer; effect of antiretroviral therapy in children of HIV positive mothers; mTOR complexes in GM3 mediated melanoma metastasis and as a strategy in oncology; and the role of fluoride and pH in titanium corrosion in the oral cavity.