This two-volume set (CCIS 1393 and CCIS 1394) constitutes selected and revised papers of the 4th International Conference on Advanced Informatics for Computing Research, ICAICR 2020, held in Gurugram, India, in December 2020. The 34 revised full papers and 51 short papers presented were carefully reviewed and selected from 306 submissions. The papers are organized in topical sections on computing methodologies; hardware; networks; security and privacy.