The only up-to-date definitive reference source on hemophilia This book is an invaluable resource that provides an overview of all aspects of the care of patients with haemophilia. Covering how to assess both bleeding children and adults, Haemophilia A and B, molecular basis of the disease, the role of factors in coagulation, epidemiology, pharmacokinetics, and treatment of inhibitors. There will also be a section on musculoskeletal aspects of haemophilia as well as newer developments such as gene therapy and rare bleeding disorders. Textbook of Hemophilia is ideal for: Trainees and residents in hematology Hematologists in practice Specialists working in thrombosis and hemostasis as well as transfusion medicine Why Buy This Book? The only up-to-date definitive reference source on hemophilia Essential for all those managing hemophilia patients Detailed guidance on assessment, diagnosis, management and treatment Advice for everyday clinical questions Edited by three of the world's leading experts on hemophilia SUBJECT: Haemophilia is an inherited disorder of blood clotting. It is a lifelong condition for which, at present, there is no cure. Normal blood clotting depends on the interaction of many substances within the blood, including clotting factors. If one of these factors is not present in sufficient amounts prolonged bleeding may occur. With the development of comprehensive care and the provision of preparations containing the missing clotting factors, it is possible for people with even severe haemophilia to control bleeding and live near normal lives. Haemophilia affects males almost exclusively and is found in all populations. It is passed on by women who usually have no bleeding problems and occurs in about 1:5,000 males births. NEED: As haemophilia is life-long, continuing supervision by a group of medical personnel is desirable. In many countries this is provided by comprehensive care haemophilia centres where staff of all specialities concerned with treatment- haematologists, paediatricians, nurses, physiotherapists, orthopaedic surgeons - have specialized knowledge. There is now a need for a new definitive textbook on all aspects of haemophilia including diagnosis, management and treatment. There are many complex issues surrounding treatment as the condition is treated by replacing the deficient blood clotting factor through transfusion into veins. There is therefore a problem with the risk of transmission of viruses such as HIV. COMPETITION: The only definitive reference sources on haemophilia currently available are extremely out-of-date. Several of the editors involved with these other books have since retired and many of the contributors no longer work in the field of inherited bleeding disorders. There are several books published by organisations, such as the World Federation of Hemophilia, but these are predominantly aimed at patients and their families. FORMAT: The book will be divided into 18 major sections. It will begin with an overview of haemostasis and cellular processing of factors, then give guidance on how to assess both bleeding children and adults. Both Haemophilia A and B will be discussed in detail and there will be coverage of the molecular basis of the disease, the role of factors in coagulation, epidemiology, pharmacokinetics, and treatment of inhibitors. There will also be a section on musculoskeletal aspects of haemophilia as apart from bruising, haemorrhages into the joints are the most common feature of the condition. The current products used to treat haemophilia will be covered, specifically recombinant factor and plasma-derived factor. Newer developments such as gene therapy and the molecular engineering of these factors will also be addressed. A section will be dedicated to the rare bleeding disorders and the book will conclude with chapters on comprehensive care and its delivery worldwide. FEATURES: Essential, definitive reference source for all those managing haemophilia patients Provides detailed guidance on assessment, diagnosis, management and treatment Highlights controversial issues and provides advice for everyday clinical questions Over 60 international contributors with world expertise in caring for haemophilia patientsMARKETING: We have a major prescence in haematology and haemophilia through our journals and affiliation to the World Federation of Hemophilia and the International Society of Thrombosis and Hemostasis. This should give us unparralleled access to the haemophilia community, both in Europe and the USA. SUPPORT: The book will be edited by three of the world's experts on haemophilia - Christine Lee from London, UK Keith Hoots from Texas, USA and Eric Berntop from Malmo, Sweden. All run large comprehensive care centres and have a strong research program in place at their hospitals. They have recruited over 60 international contributors and each is well known in the field of haematology and bleeding disorders. SUMMARY: The Textbook of Hemophilia will be an invaluable resource that provides an overview of all aspects of the care of patients with haemophilia.