This book is a study of the neurobiology of Alzheimer's disease. The authors critically review the established and accepted culprit in Alzheimer's disease, the amyloid, the main molecular factor of neurodegeneration in this disease. This book provides a synopsis of current information about ischemic cellular and molecular mediators involved in Alzheimer's neuropathology as well as interactions between these mediators that influence pathology. Current knowledge on the relation between ischemia-reperfusion factors and Alzhemier's-type demential are reviewed as well as the linking of B-amyloid deposition to neuronal damage and clinical disease.