When his healing factor fails, Wade Wilson grudgingly turns to Dr. Killebrew, the mad scientist who cured his cancer--and ruined his life!

But what exactly was done to Deadpool in the Workshop? And can Wade control his impulse to slice Killebrew into little pieces?

Then, Ajax wants Deadpool's stain scrubbed from the planet. What is his connection to Wade's nightmarish origin--and how is Death herself involved?

Plus: The resurrected Weapon X program makes Wade an offer he can't refuse: If he joins their cutthroat crew, they'll fix his ravaged face!

And when Deadpool is haunted by the ghosts of his past, can fellow Weapon Plus alumni Wolverine and Captain America help him through his most harrowing battle ever?

Collects: DEADPOOL (1997) #3-5, #17-19 and #57-61; DEADPOOL/DEATH ANNUAL '98; and DEADPOOL (2012) #15-19.